My Blog

Epilepsy is a neurological disorder characterized by recurrent seizures, and it affects millions of people- adults and children, worldwide. While medications are the primary treatment for epilepsy, there is growing evidence that dietary interventions, specifically the ketogenic diet, can be a valuable adjunct therapy for managing seizures, particularly in children. Here, we will explore the ketogenic diet, its potential benefits for epilepsy, the target population, and the importance of medical supervision when implementing this dietary approach.

The Ketogenic Diet: Introduction and Mechanism

The ketogenic diet is a high-fat, low-carbohydrate, and moderate-protein diet that induces a metabolic state called ketosis. Normally, the body primarily uses carbohydrates as its main source of energy. However, without carbohydrates, such as fasting or following a low-carb diet, the body shifts its fuel source to fat metabolism. This metabolic adaptation produces ketone bodies, which are utilized as an alternative energy substrate by the brain and other tissues. Higher levels of ketones in the blood have been found to have anticonvulsant effects, providing a potential mechanism for the therapeutic benefits of the ketogenic diet in epilepsy.

Ketogenic Diet Efficacy in Epilepsy

The ketogenic diet has demonstrated efficacy in various forms of epilepsy, particularly in specific generalized childhood epilepsies such as infantile spasms, tuberous sclerosis, Dravet syndrome, Doose syndrome, and GLUT-1 deficiency. The ketogenic diet is often used alongside standard antiepileptic medications in these conditions. 

It is important to note that the ketogenic diet may be more effective in children than adults and limited data support its use in adults. Furthermore, individuals with underlying metabolic or mitochondrial disorders should avoid the ketogenic diet due to potential complications.

Understanding the Ketogenic Diet Ratio

The ketogenic diet is typically prescribed and monitored by a multidisciplinary team consisting of an epileptologist (a neurologist specialized in epilepsy) and a registered dietitian or nutritionist. The diet is defined by a “ratio,” which represents the combined ratio of fat to carbohydrate and protein grams. The most commonly used ratio is 4:1, indicating a higher fat content than protein and carbohydrates. 

For infants, adolescents, and children requiring higher amounts of protein or carbohydrate, a 3:1 ratio may be prescribed. Foods rich in fat, such as butter, heavy whipping cream, mayonnaise, and oils (e.g., canola or olive oil), are the primary energy sources in the ketogenic diet. Careful meal planning and restriction of other sources of carbohydrates are crucial to maintaining the appropriate ratio.

Hospital Initiation and Supervision

The ketogenic diet initiation typically begins in a hospital setting, under close medical supervision. Traditionally, children start the diet by fasting for 18-24 hours, except for water. This initial fasting period helps induce ketosis. After the fasting period, the diet is gradually introduced, either by increasing calories or adjusting the ratio. 

Closely monitoring the child’s nutritional intake and overall health is essential throughout the diet’s implementation. The dietitian plays a key role in educating parents and children about suitable food choices and meal preparation. 

At the same time, the neurologist closely monitors seizure medication levels, triglyceride and lipid profiles, liver, and kidney function, as these parameters can be affected by the ketogenic diet. Please note that Johns Hopkins Hospital uses this protocol, but it might not be the traditional protocol at all centers. 

Positive Outcomes in Children with Epilepsy

Numerous studies have reported positive outcomes in children with epilepsy following the ketogenic diet. In fact, over half of the children who adhere to the diet experience a significant reduction in seizure frequency, often by at least 50%. The ketogenic diet’s success has led to the establishment of specialized ketogenic diet centers in major pediatric hospitals worldwide.

Conclusion

The ketogenic diet has emerged as a promising adjunct therapy for epilepsy, especially in children with specific generalized epilepsies. The diet may exert anticonvulsant effects by inducing a metabolic state of ketosis and increasing ketone levels. 

However, it is crucial to note that the ketogenic diet should only be implemented under the supervision of a nutritionist and epileptologist, as it requires meticulous meal planning, monitoring of nutrient intake, and adjustment of medications. While the ketogenic diet has shown efficacy in reducing seizures in many children, further research is needed to explore its long-term effects and its potential benefits in adults with epilepsy.

References: 

1. Barry D, Ellul S, Watters L, Lee D, Haluska R Jr, White R. The ketogenic diet in disease and development. Int J Dev Neurosci. 2018 Aug;68:53-58. doi: 10.1016/j.ijdevneu.2018.04.005. Epub 2018 Apr 22. PMID: 29689338.

2. D’Andrea Meira I, Romão TT, Pires do Prado HJ, Krüger LT, Pires MEP, da Conceição PO. Ketogenic Diet and Epilepsy: What We Know So Far. Front Neurosci. 2019 Jan 29;13:5. doi: 10.3389/fnins.2019.00005. PMID: 30760973; PMCID: PMC6361831.

3. Dhamija R, Eckert S, Wirrell E. Ketogenic diet. Can J Neurol Sci. 2013 Mar;40(2):158-67. doi: 10.1017/s0317167100013676. PMID: 23419562.

4. Martin-McGill KJ, Bresnahan R, Levy RG, Cooper PN. Ketogenic diets for drug-resistant epilepsy. Cochrane Database Syst Rev. 2020 Jun 24;6(6):CD001903. doi: 10.1002/14651858.CD001903.pub5. PMID: 32588435; PMCID: PMC7387249.

5. Perucca P, Scheffer IE, Kiley M. The management of epilepsy in children and adults. Med J Aust. 2018 Mar 19;208(5):226-233. doi: 10.5694/mja17.00951. PMID: 29540143.

6. Ruan Y, Chen L, She D, Chung Y, Ge L, Han L. Ketogenic diet for epilepsy: an overview of systematic review and meta-analysis. Eur J Clin Nutr. 2022 Sep;76(9):1234-1244. doi: 10.1038/s41430-021-01060-8. Epub 2022 Jan 13. PMID: 35027683.

1. Wells J, Swaminathan A, Paseka J, Hanson C. Efficacy and Safety of a Ketogenic Diet in Children and Adolescents with Refractory Epilepsy-A Review. Nutrients. 2020 Jun 17;12(6):1809. doi: 10.3390/nu12061809. PMID: 32560503; PMCID: PMC7353240

The post The Ketogenic Diet and Epilepsy- a non-pharmacological treatment option appeared first on Cast Iron Keto.